Peroxisomal biogenesis disorders (PBDs)—also referred to as Zellweger spectrum disorder—is a genetic metabolic disorder affecting children.  Those with the disease have upwards of 50 biochemical abnormalities.  While the spectrum ranges, the prognosis is grim: anywhere from death within the first year to survival into early adulthood with severe special needs.

Children living with the disease suffer from profound vision and hearing loss, seizures and significantly impaired cognition.

Estimates vary, but the incidence of PBD is believed to be between 1 in 25,000 and 1 in 50,000.